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Figure 3


Fig. 3. Involvement of N-WASP in Exo70-induced membrane protrusion growth of NGF-differentiated PC12 cells. (A) Morphometric irregularity index analysis of NGF-induced PC12 cells expressing HA-tagged N-WASP, N-WASP{Delta}cof or N-WASP-H208D either with empty vector (light grey columns) or with FLAG-Exo70 (dark grey columns). (B) Irregularity indexes of NGF-induced PC12 cells transfected with control or N-WASP siRNA either with empty vector (light grey columns) or with FLAG-Exo70 (dark grey columns). Shown are averages ± s.e.m. Statistical significance is indicated relative to control cells expressing empty vector (light grey columns) or to cells expressing only Exo70 (dark grey columns). Significance for data in A and B: *P<0.05, **P<0.01, ***P<0.001 (Student's t-test). The efficiency of siRNA-mediated knockdown of N-WASP (~65% as judged by densitometry) for N-WASP relative to actin is shown in the western blot.





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