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Figure 1


Fig. 1. The NER response to local pulsed 800 nm laser irradiation. (A) XPC-GFP-expressing cells were irradiated through a filter with UV-C light (spots indicated by arrows) and subsequently treated with 800 nm laser pulses (lines indicated by arrowheads). Induction of CPDs is shown by staining with the CPD antibody (red, right panel) both on UV-C and pulsed 800 nm locally irradiated areas. In both areas XPC-GFP accumulated (green, left panel). (B) XPC-GFP-expressing cells were treated as in panel A and stained for the presence of 6-4PPs (red, right panel). Pulsed 800 nm irradiation is able to induce 6-4PP-formation as shown by the lines indicated by the arrowheads (right panel). The bar graph indicates fluorescence intensities of the nucleus (1), pulsed 800 nm induced local damage (2) and UV-C induced local damage (3). (C) GFP-XPA accumulates to a limited extent on pulsed 800 nm induced damaged areas (arrowhead) compared to UV-C irradiated areas (arrow). The bar graph indicates fluorescence intensities of the nucleus (1), pulsed 800 nm induced local damage (2) and UV-C induced local damage (3).





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