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Figure 10


Fig. 10. dab-1 mutants are sensitive to loss of AP-1 and AP-3 function. DIC images showing terminal phenotypes associated with single- and double-mutant combinations. (A) dab-1(gk291) mutant showing wild-type embryonic morphogenesis and viability. (B) An apb-3(ok429) homozygous embryo, displaying characteristic `dumpy' (Dpy) morphology; arrow indicates presence of gut granules in the intestinal lumen. (C) An unc-101(sy108) embryo showing wild-type morphogenesis and viability. (D) An apb-1(ok429); dab-1(gk291) double-mutant embryo, which displays the same Dpy phenotype and gut granule defect (arrow) as ok429 single mutants. (E) An unc-101(sy108); dab-1(gk291) double-mutant embryo showing the synthetic body morphology defects seen in approximately 30% of unc-101; dab-1 double mutants. Arrowheads indicate vacuoles located at the approximate position of the excretory cell sometimes seen in the double-mutant embryos. Embryos are approximately 50 µm in length.





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