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First published online July 23, 2007

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A different class of RNA

RNA molecules are already known to regulate a variety of biological processes – from transcription and translation to protein targeting and genomic imprinting. And as more and more types of RNA are discovered, new and unexpected roles for these molecules are being revealed. On p. 2498, Shinichi Nakagawa and colleagues describe a novel RNA that has the molecular features of an mRNA, but does not behave like one. This mRNA-like noncoding RNA – called Gomafu – caught the researchers attention during a screen for genes expressed in a subset of neurons. The researchers were particularly interested in its nuclear localisation. Different regions of the nucleus have different roles in transcription, splicing, ribosome processing and assembly, but Gomafu is not localised with any other known non-coding RNA, nuclear domain or particular chromosome. Instead it seems to be associated with the nuclear matrix, with which a variety of factors involved in transcription, replication and DNA repair are linked. The researchers suggest that Gomafu represents a new class of RNA and could therefore be key to uncovering yet more roles for these molecules.

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Related articles in JCS:

The mRNA-like noncoding RNA Gomafu constitutes a novel nuclear domain in a subset of neurons

Masamitsu Sone, Tetsutaro Hayashi, Hiroshi Tarui, Kiyokazu Agata, Masatoshi Takeichi, and Shinichi Nakagawa
JCS 2007 120: 2498-2506. [Abstract] [Full Text]  

This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Related articles in JCS Similar articles in this journal Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via Google Scholar Google Scholar Search for Related Content Social Bookmarking                         What's this?