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First published online July 23, 2007

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Miz1 – the bald facts

The transcription factor Miz1 is expressed in hair follicles and keratinocytes. It controls cell proliferation and is involved in regulation of gene expression by TGF. Now, Hans-Peter Elsässer and colleagues (p. 2586) have investigated its important role in hair morphogenesis and follicle structure. The researchers created conditional mutants lacking Miz1 expression in keratinocytes. These mice have rough fur – owing to an alteration in the orientation and structure of hair follicles. They also have a pronounced delay in the onset and progression of catagen (the regression phase of hair development), something also seen in mice lacking TGF. Furthermore, the epithelium in these mice is thicker at the top of the hair follicles (where the hair follicle epithelium becomes the interfollicular epithelium), owing to increased keratinocyte proliferation. This prompted the authors to investigate the roles of Miz1 in TGF-mediated gene regulation. They observe reduced expression of several TGF targets in cultured Miz1-deficient keratinocytes, and discuss the roles of Miz1 and TGF in controlling proliferation and differentiation during hair morphogenesis and generation of follicle structure.

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Related articles in JCS:

Miz1 is required for hair follicle structure and hair morphogenesis

Anneli Gebhardt, Christian Kosan, Barbara Herkert, Tarik Möröy, Werner Lutz, Martin Eilers, and Hans-Peter Elsässer
JCS 2007 120: 2586-2593. [Abstract] [Full Text]  

This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Related articles in JCS Similar articles in this journal Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via Google Scholar Google Scholar Search for Related Content Social Bookmarking                         What's this?