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Fig. 1. Bone densitometric, morphological and biomechanical characteristics of Sox4^+/– mice compared with WT. (A) BMC-changes with age measured with DXA in WT and Sox4^+/– mice (n=11-24). Mean age for each measurement: 48, 70, 104, 134, 168, 182, 222, 260, 300, 335 and 374 days. The growth curves for each genotype in both genders (corrected for body weight and bone area) were significantly different (P<0.001) throughout the observation period. Plots of mean BMC ± s.d. (WT males and females: n=24; Sox4^+/– males: n=11, Sox4^+/– females: n=14). Error bars on one side were omitted for clarity. (B) Microarchitecture of diaphyseal and metaphyseal bone from WT and Sox4^+/– mice analyzed by µCT. Typical example of femurs from 3-month-old males, left: diaphysis (cortical bone), right: methaphysis (trabecular bone). (C) Cortical bone volume (Cort. BV), cortical thickness, trabecular bone volume (Trab. BV/TV, %) and trabecular thickness in 3-month-old males. Bars, mean ± s.d. (WT: n=11, open bars; Sox4^+/–: n=8, solid bars). For cortical thickness, P=0.052. (D) Dynamic assessment of mineral acquisition rate (MAR) in WT and Sox4^+/– mice. Fluoroscopic microphotograph showing fluorochrome labeling in a 3-month-old female injected with Alizarin (red) and calcein (green) 10 and 3 days before sacrifice, respectively. Distance between arrows: MAR during 7 days (see Table 3 for quantitative analysis). (E) Bone formation rate/bone surface/year (BFR/BS/year) in 3-month-old males treated as described in D. Bars, mean ± s.d. (WT: n=5, open bars; Sox4^+/–: n=4, solid bars). (F) Biomechanical properties: moment of inertia (Ix) and stiffness in femurs from 3-month-old males, presented as mean ± s.d. (WT: n=11, open bars; Sox4^+/–: n=8, solid bars). ^***P<0.001; ^*P<0.05 compared with WT.

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