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Figure 8


Fig. 8. Spindle checkpoint activation by cytochrome oxidase inhibitor. gEGFP-Mps1 embryos were incubated in either absence (–CN) or presence (+CN) of cyanide for 5 (A) or 15 (B) minutes before fixation and labeling with anti-{alpha}-tubulin (Tub) and a DNA stain (DNA). Cyanide induces reorganization of EGFP-Mps1 (Mps1), microtubules and chromatin during metaphase (A) and interphase (B) that is indistinguishable from the effects of anoxia. Bar, 5 µm.





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