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Figure 4


Fig. 4. Shroom2, myosin VIIa and ZO-1 in the mouse retina. (A-F) Sections of the mouse retina at (A,B) E14 and P90 (C-F). Shroom2 is detected in the retinal pigment epithelium (RPE) cells, and some neuronal extensions in the inner region of the neuroretina. (C-F) Shroom2 is concentrated at the TJs, where it is co-distributed with ZO-1 (red). The neuronal labeling of shroom2 persists in adults, in the inner plexiform layer (IPL). (E,F) Adjacent tangential sections of the P90 mouse retina labeled for ZO-1 and either shroom2 or myosin VIIa. Note that shroom2 is co-distributed essentially with ZO-1 at the TJ zone, whereas myosin VIIa is present throughout the cytoplasm, and in the apical microvilli. Colocalization with ZO-1 is illustrated in the confocal orthogonal (YZ) reconstructions. ONL, outer nuclear layer; INL, inner nuclear layer, GCL, ganglion cell layer. Bars, 10 µm.





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