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Figure 7


Fig. 7. Schematic diagram of the role of GSK-3beta in the signaling pathways of ceramide-induced mitochondrial apoptosis. During ceramide-induced apoptosis, activated PP2A induces GSK-3beta dephosphorylation and activation indirectly through a PI 3-kinase-Akt-regulated pathway. How ceramide activates PP2A remains unknown. Also, how GSK-3beta activates caspase-2 and caspase-8, which causes mitochondrial damage and apoptosis, needs to be deciphered. It is of particular interest to know whether there is cross-talk between GSK-3beta and Bcl-2.





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