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Fig. 3. The role of Aurora-A in centrosome maturation. In preparation for its role as a mitotic spindle pole, the centrosome undergoes maturation, a process involving the expansion of its PCM (yellow) through the recruitment of cytoplasmic factors such as 
-tubulin (-tub). On the left-hand side is an `immature' centrosome – the PCM is sparse with little associated -tubulin. According to this model, in late G2 phase, the kinase CDK11 localises Plk1, which in turn recruits Aurora-A (Aur). Once in the centrosome, Aurora-A phosphorylates several factors (red ovals) that facilitate its autoactivation. The active Aurora-A kinase then recruits NDEL1. LATS2 kinase phosphorylates Ajuba, but this does not seem to be the mechanism by which it regulates centrosome maturation. The precise hierarchy of the targeting and activation of the proteins shown here is unknown, as is the factor that recruits -tubulin to the vertebrate centrosome during the process. In Drosophila, -tubulin is recruited to the centrosome by centrosomin (CNN), a protein that binds to Aurora-A and is dependent on the kinase for its centrosomal localisation (Terada et al., 2003).
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