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Figure 5


Fig. 5. Verification of HSP60 (A), HSP70 (B) and Casp9 (C) as cognate targets of miR-1 and miR-133, respectively, for post-transcriptional repression. Data on luciferase reporter activities show the interaction between miR-1 and HSP60 and HSP70 3'UTRs and between miR-133 and Casp9 mRNA. WT, wild type; MT, mutant, AMO-1 and AMO-133, miR-1- and miR-133-specific antisense inhibitors, respectively (see Fig. 2). Shown are means ± s.e.m. (n=5 batches of cells for each bar in A-C). *P<0.05 vs Ctl; +P<0.05 vs WT miR-1 or WT miR-133.





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