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Figure 1


Fig. 1. Ninein speckle relocation to apical non-centrosomal sites during inner pillar cell development. (A) Schematic diagram of microtubule (red lines) and ninein (green) organisation in a typical inner pillar (IP) cell at postnatal day 5 (P5) showing microtubule minus-ends anchored at apical sites (arrowhead). (B) IP cell at P1 showing ninein mainly confined to the centrosome (arrow) at an early stage in the assembly of the apico-basal array. (C) Two IP cells at P3 with ninein at the centrosome and as distinct speckles in the cytoplasm of the apical half. Note that some of the ninein speckles are aligned in a peripheral apical ring (arrow). (D) IP cell at P5 double-labelled for dynein (red) and ninein (green), with ninein now evident at the apical peripheral ring (arrow) as well as at the centrosome. (E) Ninein peripheral ring in an IP at P6. (F) Apical region of an IP cell at P5 with microtubules (blue) forming an apico-basal array and {gamma}-tubulin (red) concentrated at the centrosome and not evident at the apical sites (arrow). Bars, 10 µm (A-C), 5 µm (D), 2.5 µm (E,F).





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