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Figure 2


Fig. 2. Disruption of apical or basolateral polarity leads to distinct effects on adherens junction localization. (A,C,E,G,I) DE-cadherin (green) and F-actin (red) in the wild type (A) and Exo84 (C), crumbs (E), dlg (G) and lgl (I) mutant embryos at stage 10. (B,D,F,H,J) Armadillo (green) and Neurotactin (red) in the wild type (B) and Exo84 (D), crb (F), dlg (H) and lgl (J) mutant embryos at stage 10. (A,B) In wild-type embryos, DE-cadherin (green A) and Armadillo (green B) localize to the apical edge of lateral interfaces and form a continuous circumferential band. (C-F) In Exo84 (C,D) and crumbs (E,F) mutants, DE-cadherin (green C,E) and Armadillo (green D,F) form large isolated puncta at various locations along the apical-basal axis. (G-J) In dlg (G,H) and lgl (I,J) mutants, DE-cadherin (green G,I) and Armadillo (green H,J) are diffusely distributed along the cell cortex. Anterior left, ventral up. Bars, 20 µm (A), 5 µm (B).





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