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Figure 8


Fig. 8. A model for exocyst function in epithelial polarity of the Drosophila embryo. Epithelial polarity is established correctly in Exo84 mutant embryos (A). Crumbs (red) and adherens junction proteins (blue) localize to the apicolateral cell surface, and recycling endosomes (green) are distributed throughout the apical cytoplasm. (B) Failure to traffic Crumbs to the apical surface, first apparent at stage 9, is accompanied by a loss of apical identity and a mislocalization of adherens junction proteins along the cell surface in a manner that resembles crumbs mutants. (C) At later stages, a defect in trafficking from recycling endosomes to the cell surface causes apical and adherens junction proteins to accumulate in an enlarged recycling endosome compartment.





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