spacer gif spacer gif spacer gif spacer gif spacer gif
QUICK SEARCH:   [advanced]


spacer gif
     Home     Help     Feedback     Subscriptions     Archive     Search     Table of Contents    

Right arrow Help viewing high resolution images
Right arrow Return to article
(Downloading may take up to 30 seconds.
If the slide opens in your browser, select File -> Save As to save it.)
Click on image to view larger version.


Figure 1


Fig. 1. Summary of some of the known partners and pathways of RASSF1A. RASSF1A binds to at least three microtubule-binding proteins (MAPs), complexes with microtubules and regulates mitosis, the cell cycle and apoptosis in response to mitogenic or apoptotic stimuli. Direct interaction between RASSF1A and microtubule-associated proteins localizes RASSF1A to the microtubules, stabilizing them and, thereby, regulating mitosis. Repression of cyclins A and D1 by RASSF1A results in cell cycle arrest and interactions with CNK1, MST1, Salvador and MOAP1 may allow RASSF1A to modulate apoptosis.





Right arrow Return to article