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Figure 4


Fig. 4. Cyclin A is degraded in RNAi silenced Apc6/Cdc16 and Apc8/Cdc23 cells. Columns of images show tubulin (green and second column), DNA (blue and third column) and cyclin A (red and fourth column) localisations in mitotic cells. Cyclin A staining is visible in wild-type prophase or prometaphase (A-D) but it is undetectable in most of the wild-type metaphase (E-H) cells (n=12). Similarly to this, in the majority (80%) of both Apc6/Cdc16 (I-L) and Apc8/Cdc23 (M-P) RNAi induced cells (n=19 and 26, respectively), there is no detectable cyclin A at the onset of metaphase, indicating that cyclin A degradation is not affected in these lines.





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