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Figure 7


Fig. 7. v-Src- and IL-6-mediated STAT3 activation and its inhibition. Cytokine-induced STAT3 activation (right) is transient owing to the induction of the feedback inhibitor SOCS3. Persistent activation of STAT3 by v-Src (left) requires nucleocytoplasmic shuffling. Inhibition of nuclear export blocks the reactivation cycle. See Discussion for details.





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