spacer gif spacer gif spacer gif spacer gif spacer gif
QUICK SEARCH:   [advanced]


spacer gif
     Home     Help     Feedback     Subscriptions     Archive     Search     Table of Contents    

Right arrow Help viewing high resolution images
Right arrow Return to article
(Downloading may take up to 30 seconds.
If the slide opens in your browser, select File -> Save As to save it.)
Click on image to view larger version.


Figure 1


Fig. 1. P-STAT1 is essential for the induction of external chromatin loops carrying the MHC locus in response to 24-hour IFN{gamma} treatment. FISH signals for HLA-DRA are detected in red and for the CT6 in green. (A) IFN{gamma} induction of external chromatin loops carrying the HLA-DRA gene. (B) No IFN{gamma} induction of external chromatin loops carrying the HLA-DRA gene in this STAT1-null cell line. U3A cells are tetraploid and contain four copies of chromosome 6. (C) IFN{gamma} induction of external chromatin loops carrying the HLA-DRA gene in U3A cells complemented with STAT1. (D) No IFN{gamma} induction of external chromatin loops carrying the HLA-DRA gene in U3A cells complemented with a STAT1 point mutant (Y701F) that cannot be phosphorylated by JAKs.





Right arrow Return to article