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Figure 3


Fig. 3. Analysis of the role of BRG1 and BRM in large-scale chromatin remodelling of the MHC. SW13 cells (BRG1-BRM-negative) were treated with IFN{gamma} for 24 hours where indicated. HLA-DRA is detected in red and the CT6 in green. (A) SW13 cells without IFN{gamma}. (B) SW13 cells treated with IFN{gamma}. No external chromatin loops are observed. (C) SW13 cells, complemented with BRG1 and treated with IFN{gamma}. External chromatin loops carrying the MHC are clearly observed.





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