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Figure 4


Fig. 4. Inhibition of NO production by L-NAME protects yeast cells from H2O2, but not from mammalian Bax expression, or acetic acid-induced apoptosis. (A) Comparison of the survival rate of wild-type cells upon H2O2 treatment with or without pre-incubation with L-NAME in order to inhibit NO production. *P<=0.03 versus wild type; t-test, n=3. (B) Comparison of the survival of wild-type cells upon acetic acid-induced apoptosis with or without pre-incubation with L-NAME. (C) Comparison of the survival of yeast cells (strain BY.bax) upon Bax expression for 15 hours (apoptotic inducing conditions), with or without pre-incubation with L-NAME. (D) Epifluorescence and phase-contrast micrographs of untreated and H2O2-treated (1.5 mM) wild-type cells, with or without pre-incubation with L-NAME, stained with dihydrorhodamine 123 (DHR123) as an indicator of high intracellular ROS accumulation. Bars, 5 µm.





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