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Figure 7


Fig. 7. Deletion of GAPDH isoform 2 and 3 prevents H2O2-induced apoptosis. (A) Comparison of the survival of wild-type, {Delta}tdh2 and {Delta}tdh3 cells upon H2O2 treatment, *P<=0.03 versus wild type, t-test, n=3. (B) Epifluorescence and phase-contrast micrographs of untreated and H2O2-treated (1.5 mM) wild-type, {Delta}tdh2 and {Delta}tdh3 cells, stained with dihydrorhodamine 123 (DHR123) as an indicator of high intracellular ROS accumulation. Bar, 5 µm.





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