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First published online September 18, 2007

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Fidgetin' through mitosis

Cell proliferation and differentiation must be precisely coordinated during development, but how is this accomplished? Lionel Pintard, Matthias Peter and colleagues have been studying this question in the C. elegans germ line. They now report that the conserved AAA ATPase Fidgetin-like 1 (FIGL-1) controls mitotic progression and that ubiquitin-dependent degradation regulates FIGL-1 levels in cells at different developmental stages (see p. 3179). In nematodes, as germ cells develop, they move from a mitotic zone in the developing gonad into a meiotic zone. The authors show that loss of figl-1 function traps germ cells in the mitotic zone, possibly by disrupting microtubule functions that are essential for mitotic progression – AAA ATPases often inactivate multiprotein complexes. They also report that FIGL-1 interacts with the CUL-3-based ubiquitin-ligase (E3) substrate adaptor MEL-26, which targets proteins for ubiquitin-dependent degradation. From these and other results, the authors propose that degradation of FIGL-1 by the CUL-3^MEL-26 E3 ligase spatially restricts its function to mitotic cells in the developing gonad, where it is required for progression through mitosis.

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Related articles in JCS:

The AAA-ATPase FIGL-1 controls mitotic progression, and its levels are regulated by the CUL-3^MEL-26 E3 ligase in the C. elegans germ line

Sarah Luke-Glaser, Lionel Pintard, Mike Tyers, and Matthias Peter
JCS 2007 120: 3179-3187. [Abstract] [Full Text]  

This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Related articles in JCS Similar articles in this journal Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via Google Scholar Google Scholar Search for Related Content Social Bookmarking                         What's this?