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Figure 7


Fig. 7. Model illustrating the nesprin-3 LINC complex. Nesprin-3{alpha} dimers (blue) are retained at the ONM through an interaction with Sun1 (brown) or Sun2 (green) protein dimers. The binding of nesprin-3{alpha} to dimers of plectin (yellow) connects the nucleus to the intermediate filament system. A potential interaction of Sun proteins with lamin A (red), indicated by a question mark, establishes an indirect link between the cytoskeleton and the nucleoskeleton: the nesprin-3 LINC complex. ONM, outer nuclear membrane; INM, inner nuclear membrane; PS; periplasmic space; IF, intermediate filaments.





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