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Figure 5


Fig. 5. ErbB2/ErbB3 expression enhances directed migration in tumour cell electotaxis. MTLn3 and MDA-MB-435 cells were transduced with either empty vector (PLXSN alone) or PLXSN containing the cDNAs for ErbB1, ErbB2 or ErbB3. Cells were plated on collagen-1-coated dishes overnight and starved in serum-free {alpha}-MEM for 2-3 hours before EF exposure. (A) An EF of 0.5 V/cm was applied to MTLn3 cells for 2 hours. *P<0.05, **P<0.01 compared with MTLn3-PL cells. (B) An EF of 2 V/cm was applied to MDA-MB-435 cells for 2 hours. Directedness of cell migration in an EF was increased for all three lines transduced with ErbB1, ErbB2 or ErbB3. *P<0.05; **P<0.01 compared with 435-PL cells. Data are mean ± s.e.m from three independent experiments on more than 200 cells.





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