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Figure 6


Fig. 6. PI3K and Rho family small GTPases are partly involved in the directional migration of tumour cells in electrotaxis. (A,B) MTLn3 cells were pretreated with Ly294002 (50 µM) or Genistein (100 µM; Geni) for 2 hours before EF application. PI3K inhibitor Ly294002 (Ly) only slightly (but statistically significantly) inhibited displacement speed and anodal directedness (*P<0.01 compared with EF alone), but Genistein can significantly block migration speeds and directedness in electrotaxis (**P<0.001 compared with EF alone). (C,D) Cells were pretreated with Toxin B (10 ng/ml), or the peptide LS201 (RhoA inhibitor, 100 ng/ml), LS202 (Rac inhibitor, 100 ng/ml) or LS203 (Cdc42 inhibitor, 100 ng/ml) for 2 hours before EF stimulation. *P<0.01 compared with no inhibitor control; ^P< 0.05 compared with LS201, LS202; ^^P<0.01 compared with LS202. Data are presented as mean ± s.e.m. Data shown are from three independent experiments. EF=1.5 V/cm, 2 hours.





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