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Figure 8


Fig. 8. Schematic diagram of the electrical gradient in the breast duct. A 30 mV transepithelial electrical potential difference (TEP) (the difference between the apical and the basolateral potentials) exists, with the lumen side positive (Faupel et al., 1997). This would generate a voltage of 6 V/cm across the epithelium layer (30 mV over 50 µm), which is up to ten times greater than the EF strengths used in our experiments. The vector of this EF (minus to plus) with the anode in the lumen coincides with the direction of the first metastasis of breast cancer cells, in which the cells migrate into the lumen (Wellings and Jensen, 1973).





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