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Figure 7


Fig. 7. Hypothetical model explaining HP1 plasticity. (A) Characteristic patterns of HP1 proteins in different cell types and developmental states that could be used as tools for epigenetic cell typing. Images collected in the course of this study have been artistically modified to highlight the variations in HP1 localization. (B) Potential microscopic states and equilibria involving HP1 proteins. The central concept in this model is that HP1 proteins are involved in multiple interactions, including self-association and binding to chaperones or assembly factors (gray circle S). A small fraction of HP1 (black circles with inner green circle) binds stably to chromatin, whereas a greater fraction (red, blue and green circles) associates weakly with chromatin territories through me3K9-H3 or pre-existing HP1. A sub-population of HP1 molecules `scan' chromatin in a perpetual fashion, whereas another proportion remain freely diffusible in the nucleoplasm. For more details see Discussion.





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