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Figure 7


Fig. 7. Model of endocytic control of Dome trafficking and JAK/STAT signalling. Dome intracellular trafficking in egg chambers. Following ligand binding, Dome is directed to the early endosome and is then sorted to the lysosome, via the multivesicular body (MVB) and the late endosomal compartment. The off/on/off model (right): to become active, the JAK/STAT signalling pathway requires the formation of the ligand-receptor complex at the cell membrane and the formation of Chc-containing budding vesicles. These two conditions allow JAK/STAT signalling to be activated only when the receptor is on its way to degradation. Finally, the degradation of Dome in the MVB/lysosome eliminates active receptors, thus dynamically controlling JAK/STAT pathway activity.





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