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First published online September 19, 2007

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Internal affairs – the STATs

JAK/STAT signalling couples various receptors to regulation of gene expression, controlling many aspects of the immune system and several developmental pathways. On p. 3457, Stéphane Noselli and colleagues investigate the role of receptor endocytosis in this pathway. Using Drosophila melanogaster follicle cells as a model, they focus on the interaction between the ligand Unpaired and its receptor Dome. Using endocytic markers, they identify Dome in early and late endosomes and show that it is mislocalised in cells that have a mutated clathrin heavy chain. The authors therefore suggest that clathrin-mediated internalization controls the amount of Dome available for ligand interactions. By monitoring the activity of STAT transcription factors, they also demonstrate that mutations in several components of the endocytic pathway block signalling. This shows that both internalization and trafficking are required for JAK/STAT signalling; however, the authors were surprised to find that mutations in Rab11 – a protein specifically required for recycling from endosomes – do not affect STAT activity. Consequently, they conclude that that ligand-bound Dome is targeted to the lysosome for both signalling and degradation, suggesting that endocytosis, but not recycling, regulates JAK-STAT signalling.

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Related articles in JCS:

The endocytic control of JAK/STAT signalling in Drosophila

Olivier Devergne, Christian Ghiglione, and Stéphane Noselli
JCS 2007 120: 3457-3464. [Abstract] [Full Text]  

This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Related articles in JCS Similar articles in this journal Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via Google Scholar Google Scholar Search for Related Content Social Bookmarking                         What's this?