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First published online September 19, 2007

Journal of Cell Science 120, 1905e (2007)
© The Company of Biologists Limited
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In this issue

Chronic inflammation clarified


Figure 1

Chronic inflammation in tissues is characterised by the persistence of leukocytes, continual tissue damage and tissue repair. On p. 3372, Anna Huttenlocher and colleagues describe the first zebrafish model of chronic inflammation and use it to investigate the role of hepatocyte growth factor activator inhibitor 1 (HAI-1, a cell-surface-bound serine protease inhibitor) in the recruitment of neutrophils. The zebrafish has emerged as a useful model of human immunity – its transparency means that immune cells can be tracked easily. HAI-1 mutants – which the researchers identified during a large insertional mutagenesis screen – have a phenotype reminiscent of the human skin condition psoriasis: abnormal epithelial morphology, epidermal hyperproliferation, and inflammation in areas of hyperproliferation. The researchers show that neutrophils behave very differently in response to chronic inflammation than they do in response to wounding. They also show that the HAI-1-mutant phenotype can be rescued by knocking down the type II transmembrane serine protease matriptase, concluding that matriptase functions downstream of HAI-1 in regulation of epidermal proliferation and inflammation.


Related articles in JCS:

Live imaging of chronic inflammation caused by mutation of zebrafish Hai1
Jonathan R. Mathias, M. Ernest Dodd, Kevin B. Walters, Jennifer Rhodes, John P. Kanki, A. Thomas Look, and Anna Huttenlocher
JCS 2007 120: 3372-3383. [Abstract] [Full Text]  




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