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Figure 3


Fig. 3. Putative network of actin-regulatory proteins present in spines. The actin-severing activity of cofilin depends on a balance of various kinases and phosphatases (e.g. LIMK and CN/PP2B). The binding of cofilin to actin affects filament structure and lowers the actin affinity of drebrin at these sites. The actin stabilizer drebrin prevents actin reorganization by negatively regulating the binding of myosin to actin filaments and by interacting with gelsolin. Myosin stabilizes and contracts F-actin structures. Myosin motor activity can be triggered through PAK but also by other means. Gelsolin severs actin in a Ca2+-dependent manner and caps the barbed ends of filaments, allowing control of actin polymerization at these sites.





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