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Figure 4


Fig. 4. Facilitated migration of implanted Schwann cells infected with Ad-Cdc2 viral vectors in the injured sciatic nerve. (A) Representative images of Schwann cells infected with Ad-wt-Cdc2 and Ad-GFP in the sciatic nerve sections. Seven days after injury, infected Schwann cells (marked in circles) were identified by co-infected GFP reporter above the background staining with NF-200 or with Hoechst 33258 nuclear staining. (B) Distribution of implanted Schwann cells along the nerve. In 3 d.p.c. and 7 d.p.c. groups, Schwann cells infected with wt-Cdc2 virus were observed in the more distal portion of the nerve compared with those infected with dn-Cdc2 virus. Arrow indicates site of injury. (C) Quantitative comparison of infected cells in the distal portion of the sciatic nerves. In the sciatic nerves prepared at 3 d.p.c. or 7 d.p.c., statistical comparisons were made between the groups infected with wt-Cdc2 and dn-Cdc2 viruses (asterisks marked to the left of the symbols indicating wt-Cdc2 viral infection; *P<0.05, **P<0.01, *P<0.001; n=4, mean ± s.e.m.). Bars, 100 µm (A); 300 µm (B).





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