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Fig. 7. Effect of Cdc2 activity on neurite outgrowth of DRG sensory neurons. (A) Representative images of neurite outgrowth of DRG sensory neurons under different culture conditions. Dissociated cells were prepared from DRGs (lumbar 4-5) and sciatic nerves of animals that had or had not been subjected to preconditioning injury in the sciatic nerves (7 d.p.c.). Pre, injury preconditioned; Non-pre, non-preconditioned; SN, sciatic nerve. The primary sensory neurons and Schwann cells so derived were co-cultured. Cells were visualized by NF-200 immunostaining. (B) Quantification of neurite outgrowth of DRG sensory neurons. The number of neurite branch points in DRG sensory neurons co-cultured with Schwann cells of the sciatic nerve was significantly decreased by 10 µM roscovitine treatment. (**P<0.01; n=4). Bar, 50 µm.
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