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Figure 7


Fig. 7. Tiam1 is activated in Abeta-stimulated hippocampal cells. (A) Membrane fractions from hippocampal cells, either untreated (control) and stimulated for 4 and 24 hours with 10 µM of fibrillar Abeta1-42, were obtained. Samples were analyzed by immunoblotting using Tiam1 antibody and the values were normalized against flotillin. Tiam1 expression in the cytoplasmic fraction was analyzed by immunoblotting using Tiam1 antibody and actin as a loading control. (B) Tiam1 was immunoprecipitated from control hippocampal neurons and neurons treated for 4 hours with Abeta1-42. Phosphorylation levels were tested by immunoblotting using P-Thr monoclonal antibody. *P<0.05.





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