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Figure 9


Fig. 9. Tiam1 mediates Rac1 activation through Ca2+ signaling in Abeta-stimulated hippocampal cells. Hippocampal neurons were incubated for 4 hours with Abeta1-42 in the presence of BAPTA-AM (A) or Gö6976 (B) and then the active Rac1 fraction was pulled-down using the PAK-PBD binding domain. The active form of Rac1 was revealed using Rac1 monoclonal antibody. **P<0.01.





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