QUICK SEARCH:   [advanced] Author: Keyword(s):
Home     Help     Feedback     Subscriptions     Archive     Search     Table of Contents

First published online January 10, 2007

This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Related articles in JCS Similar articles in this journal Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via Google Scholar Google Scholar Search for Related Content Social Bookmarking                         What's this?

Home for cells

cells, the insulin-producing cells lost in type I diabetes, were thought to reside only in the pancreas. Now, during detailed analysis of mouse livers, Dutton et al. (p. 239) have uncovered another source of cells: the liver. The cells are located within extra-hepatic bile ducts and have elevated levels of insulin mRNA, the proteolytically cleaved insulin C-peptide and insulin-containing secretory granules characteristic of pancreatic cells. Furthermore, isolated hepatic ducts containing these cells can secrete insulin in response to glucose. Using specific genetic markers to identify liver cells, the authors demonstrate that the cells originate directly from liver epithelium rather than the pancreas. Attempts to replace or increase the number of cells, in the treatment of type I diabetes have been hindered by the limited supply of pancreatic islets. The identification of this novel source of cells offers renewed hope for the treatment of diabetes.

CiteULike    Complore    Connotea    Del.icio.us    Digg    Reddit    Technorati    Twitter    What's this?

Related articles in JCS:

cells occur naturally in extrahepatic bile ducts of mice

James R. Dutton, Naomi L. Chillingworth, Daniel Eberhard, Claire R. Brannon, Mark A. Hornsey, David Tosh, and Jonathan M. W. Slack
JCS 2007 120: 239-245. [Abstract] [Full Text]  

This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Related articles in JCS Similar articles in this journal Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via Google Scholar Google Scholar Search for Related Content Social Bookmarking                         What's this?