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First published online January 10, 2007

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Eph-ective cell repulsion

Eph receptor tyrosine kinases and their membrane-bound ephrin ligands control cell movement in several developing tissues. Activation of Eph receptors (EphBs) through cell-cell contact leads to cell-cell repulsion and separation. Although several pathways have been implicated in this process, the precise mechanisms are poorly defined. Evans et al. (p. 289) establish a role for Ena/VASP – a family of cytoskeletal regulators – proteins downstream of Eph receptor signalling in Eph-mediated cell repulsion. Both soluble and substrate-bound ephrinB2 cause a repulsive response in neural tube explants by destabilising lamellipodia in the neural crest. The authors demonstrate that Ena/VASP proteins contribute to the destabilisation of neural crest lamellipodia and facilitate cell-cell repulsion at sites of ephrin activation. Ena/VASP-deficient fibroblasts display reduced repulsion in response to ephrin ligands. Moreover, Ena/VASP proteins localise to sites of Eph receptor activation and are required for internalisation of receptor-ligand complexes, which is necessary during Eph-mediated cell repulsion. This study provides significant insight into the mechanisms behind repulsive signalling and demonstrates a new link between Ephrin signalling and the Ena/VASP family.

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Related articles in JCS:

Ena/VASP proteins mediate repulsion from ephrin ligands

Iwan R. Evans, Thomas Renne, Frank B. Gertler, and Catherine D. Nobes
JCS 2007 120: 289-298. [Abstract] [Full Text]  

This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Related articles in JCS Similar articles in this journal Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via Google Scholar Google Scholar Search for Related Content Social Bookmarking                         What's this?