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First published online January 10, 2007

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Lamp light for neuronal endosomes

LAMP proteins are involved in lysosomal function and intracellular trafficking. During a bioinformatics-based search for lysosome-associated molecules, Philippe Pierre and co-workers have identified brain-associated LAMP-like molecule (BAD-LAMP), a new member of the LAMP family in mice (p. 353). This unconventional LAMP-like protein defines a new endocytic compartment in specific subsets of cortical projection neurons. Interestingly, its post-natal expression coincides with cortical synaptogenesis, indicating a possible role in this process. Unlike other LAMP family members, BAD-LAMP has a highly restricted localisation: it is enriched in distinct intracellular vesicles in defined zones along the neuronal projections. Although BAD-LAMP is endocytosed, the vesicles in which it accumulates do not contain markers for classical intracellular transport pathways. Further analysis of BAD-LAMP endocytosis in HeLa cells revealed that it constantly recycles to the plasma membrane via a dynamin/AP2-dependent mechanism. The defined expression and distribution patterns of BAD-LAMP demonstrate a role for non-conventional endocytic vesicles and membrane lipids in the maturation or function of specific cortical neurones.

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BAD-LAMP defines a subset of early endocytic organelles in subpopulations of cortical projection neurons

Alexandre David, Marie-Catherine Tiveron, Axel Defays, Christophe Beclin, Voahirana Camosseto, Evelina Gatti, Harold Cremer, and Philippe Pierre
JCS 2007 120: 353-365. [Abstract] [Full Text]  

This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Related articles in JCS Similar articles in this journal Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via Google Scholar Google Scholar Search for Related Content Social Bookmarking                         What's this?