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Figure 3


Fig. 3. Chromosome organization and division site specification. (A) Physical arrangement of the ~4 megabase pair (Mbp) Caulobacter chromosome over the course of the cell cycle. Regions on the circular chromosome are indicated by color: the origin is shown in yellow, the terminus is shown in red and loci between the two are colored in a gradient according to their position. In swarmer cells, the origin resides near the flagellar/old pole and the terminus resides near the new pole. After initiation of replication, one copy of the origin is segregated to the new pole, and other loci are partitioned as they are replicated. Just before cytokinesis, the terminus regions are separated in the final steps of chromosome segregation. (B) Localization of ParB, MipZ and FtsZ during the cell cycle. ParB associates with the parS sequence adjacent to the origin (see A). MipZ binds to ParB, and both move with one copy of parS to the new pole upon origin segregation. The FtsZ-inhibitory activity of MipZ forces FtsZ from the new pole to the midcell, where it polymerizes into the Z ring that marks the cell division site.





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