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Figure 1


Fig. 1. Mitotic defects in mitch mutants. (A-I) Larval brain neuroblasts from wild-type (A,G), mitch1 (B,D,F,H), and mitch2/mitch19B (C,E,I) were stained with orcein to visualize chromosomes. (A-E) Brains treated with colchicine and hypotonic solution. In contrast with normal 6A,XX or 6A,XY chromosome complements in wild-type (A; here from a male), mitch mutants contain many aneuploid cells, as seen in (B) 6A,XXX and (C) 7A,XY. (A indicates the number of autosomes, including the dot-like fourth chromosomes.) (D,E) Many mitch mutant cells treated with colchicine also exhibit PSCS in which the sister chromatids have become detached from each other even at the centromere. (F-I) Untreated brains. (F) Many mitotic figures in untreated mitch mutant brains have overcondensed chromosomes. During anaphase, when chromatids in wild type normally migrate equally to the poles (G), lagging chromatids are visible in mitch mutants (arrows; H,I). Bar, 5 µm.





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