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Figure 4


Fig. 4. mitch mutations disrupt chromosome segregation in both male meiotic divisions. (A-L) Testes from wild-type (A,D,E,H,J), mitch1 (B,F,L), and mitch1/mitch2 (C,G,I,K) were stained to visualize chromosomes (blue) and microtubules (green). At metaphase I (A,B,C), bivalents in the mitch mutants are positioned away from the center of the cell, either off the main axis of the spindle (arrowhead) or, more frequently, on the spindle axis but closer to one pole than the other (arrows). At anaphase/telophase I (D-G), mitch bivalents often migrate only to one pole (arrows in F,G), though sometimes lagging chromosomes are observed along with unequal segregation (arrowhead, G). These phenotypes are reiterated in the second meiotic division (H-L): chromosome mis-alignment during metaphase (I; see arrow) followed by complete nondisjunction (K; arrow). Telophase II figures lacking chromosomes are also observed (L). Bar, 5 µm.





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