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Figure 7


Fig. 7. mcph1 cooperates with mei-41 and grp in the early embryo. (A) Mitotic spindle from a pre-cortically arrested grapesZ5170 embryo resembles awol-type spindles of mcph1 embryos. Microtubules are in green and DNA in red. Scale bar: 10 µm. (B) Quantification of mcph1-like arrest in grp embryos (2-4 hours). (C) mcph1 dominantly enhances mei-41 embryonic lethality. Introduction of one copy of mcph1Z1861 into a semi-sterile mei-41 background (mei-41RT1/mei-41D5) reduces embryonic hatch rate more than threefold. (D) Immunoblotting shows slower gel mobility of MCPH1 in mei-41RT1 or grp1 embryos (1-2 hours) relative to wild type.





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