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Figure 7


Fig. 7. Schematic illustrating proposed mechanism whereby {alpha}6beta4 integrin regulates Rac and Pak to mediate Bad- and NF-{kappa}B-dependent resistance to apoptosis in mammary acini. Nonmalignant MECs differentiate into polarized-tissue-like structures that assemble an endogenous laminin-332-containing basement membrane. Laminin-ligation of {alpha}6beta4 integrin stimulates Rac to drive tissue polarity and promote resistance to apoptosis in 3D mammary acini through Pak-dependent activation of NF-{kappa}B and phosphorylation of Bad. LM-332, laminin-5; P, phosphorylated.





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