spacer gif spacer gif spacer gif spacer gif spacer gif
QUICK SEARCH:   [advanced]


spacer gif
     Home     Help     Feedback     Subscriptions     Archive     Search     Table of Contents    

Right arrow Help viewing high resolution images
Right arrow Return to article
(Downloading may take up to 30 seconds.
If the slide opens in your browser, select File -> Save As to save it.)
Click on image to view larger version.


Figure 3


Fig. 3. The mitotic distribution of RAN-GTP is abnormal in RANBP1-interfered mitoses. (A) Co-sedimentation of RAN and its effectors with MTs from mitotic cells treated with buffer (–), NOC or taxol (indicated with +). HURP and TPX2 are shown for comparison. WCE, whole cell extract; sup, supernatant. (B) Localization of AR12-reactive RAN-GTP in control and RANBP1-interfered [RANBP1(i)] prometaphases (a,c) and metaphases (b,d,e). Bars, 10 µm. Graph represents the frequency of RAN-GTP distribution phenotypes in 215 RANBP1- and 210 GL2-interfered cells. The differences were statistically significant (*P<0.02) or highly significant (**P<0.001) using the {chi}2 test.





Right arrow Return to article