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Figure 7


Fig. 7. Localization profile of N-glycosylation-defective mutants of Panx1 and Panx3. (A) A sub-population of N-glycosylation-defective pannexin mutants localized to the cell surface (red) but these proteins also exhibited an increase in intracellular localization when compared with their wild-type counterparts. Notice that specific anti-pannexin labeling was eliminated by pre-incubating the antibodies with cognate peptide. (B,C) Western blots revealed that the Panx1N254Q and Panx3N71Q mutants exist as species that are insensitive to 10 U of N-glycosidase treatment. Bars, 10 µm.





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