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Figure 7


Fig. 7. Inhibition of myosin ATPase activity directly or via MLCK, but not via Rho kinase, increases the rate of A549 cell spreading. Histogram showing the percentage of spread A549 cells plated for 30 minutes on fibronectin in the absence (Control) and presence of specific inhibitors of: myosin II ATPase (blebbistatin, 20 µM), MLCK (ML-7, 1 µM), the MLCK activator MEK (U0126, 2.5 µM) or Rho kinase (Y-27632, 20 µM). Means±s.e.m.; 200 cells/experiment, n=6; **P<0.01 versus control.





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