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Figure 8


Fig. 8. SH4-domain-mediated plasma membrane blebbing requires activity of endogenous Src. CHO N18-HASPB-GFP-expressing (A) or N18-Fyn-GFP-expressing (B) cells were treated with medium containing solvent or the indicated drugs for 3 hours (see Materials and Methods for details), fixed, stained for F-actin and evaluated for PM blebbing. Shown is the quantitative analysis of PM blebbing following drug treatment. Values are the arithmetic means of at least three independent experiments+s.d. In each experiment, over 100 cells were counted per condition.





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