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Figure 3


Fig. 3. The C-terminal linker and RHO GAP-like domains are required for the targeting of INPP5B to membranes. (A) Schematic view of INPP5B point mutant and truncation constructs. The 5-phosphatase domain is indicated in red, and the RHO GAP-like domain in green. Prenylation of the C-terminus is indicated by a zigzag line. (B) GFP-tagged INPP5B point mutant and truncation constructs (green) were transiently expressed in HeLa cells, which were fixed in methanol and labelled with antibodies against GM130. Bar, 10 µm.





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