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Figure 11


Fig. 11. Proposed model of NCAM endocytosis and trafficking. Cell surface NCAM becomes phosphorylated in response to antibody-induced clustering. This allows a subsequent ubiquitylation of NCAM leading to its internalization. Ubiquitin is cleaved after NCAM is removed from the cell surface. A small part of NCAM is degraded in lysosomes whereas the major part is recycled to the cell surface. PM, plasma membrane; EC, extracellular; IC, intracellular; P, phosphorylation; U, ubiquitylation.





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