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Figure 4


Fig. 4. Comparison of steady-state conductance properties. Equilibrium gating properties were analyzed by plotting normalized junctional conductance against transjunctional voltage and fit to the Boltzmann equation. (A) comparison of homotypic wild-type Cx50 channels (n=4) and mixed gap junctions containing both wild-type and mutant Cx50 subunits (n=6) showed similar voltage sensitivity, as indicated by the overlapping pattern of the two Boltzmann plots. The steady-state reduction in conductance was greater for mixed channels expressing both Cx46 and S50P subunits (n=8) when compared with that of the homotypic Cx46 channel (n=4), indicating an increase in voltage gating sensitivity for heteromeric channels. (B) Equilibrium gating properties displayed modest changes at positive potentials when mixed channels containing both wild-type Cx46 and Cx50 (n=6) were compared with heteromeric channels expressing wild-type Cx46 and S50P. Results are shown as the mean ± s.e.m.





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